Effect of TREM-2 Gene Silencing by RNA Interference on Inflammatory Responses in Alveolar Macrophage of Acute Lung Injury Mice Induced by Lipopolysaccharide RNA干扰沉默TREM-2对内毒素所致急性肺损伤小鼠肺泡巨噬细胞炎症反应的影响
Objective To evaluate the role of macrophage inflammatory protein-1 a ( MIP-1a) and nuclear factor-? 目的:通过观察不同潮气量机械通气大鼠肺组织巨噬细胞炎症蛋白-1a(macrophageinflammatoryprotein-1a,MIP-1a)及核因子-?
NF IL6 ( Nuclear factor for IL 6 expression) is involved in inflammatory reaction, expression of acute phase proteins and cytokines, apoptosis and suppression of tumor cells, and maintenance of macrophage immunological functions. 白介素6核转录因子(NFIL6)的功能非常广泛,它不仅参与炎症反应和急性期蛋白质基因、细胞因子基因的表达调控,还参与肿瘤的凋亡、抑制和维持巨噬细胞的免疫功能。
This study was to investigate the changes of biological characters and tumorigenicity and the chemotactic activities to immune cells of tumor cells transfected with human macrophage inflammatory protein-1 beta ( hMIP-1 β) gene. 探讨转染人巨噬细胞炎性蛋白1β(humanmacrophageinflammatoryprotein-1beta,hMIP-1β)基因的小鼠结肠腺癌CT26细胞的生物学特性、致瘤性及对免疫细胞的体内外趋化作用。
Objective To investigate the regulatory effects of activin A on activity of inflammatory macrophage cells in mouse. 目的探讨激活素A对参与炎症反应的小鼠巨噬细胞活性调节作用。
Results: Negative staining of IL 6 was found in all the cases of normal pulpal tissue while positive in all inflammatory pulp. IL 6 expression was found mainly in monocytes macrophage and in a few vascular endothelial cells and fibroblasts. 结果:正常人牙髓组织IL-6染色为阴性,炎症牙髓组织中IL-6染色均呈阳性,主要表达细胞为单核-巨噬细胞,少量血管内皮细胞和成纤维细胞。
Result: Tongbiling could inhibit inflammatory cell infiltration and fibroblast hyperplasia and macrophage like type A synoviocyte hyperplasia in CIA rats. 结果:通痹灵对CIA大鼠滑膜组织的炎性细胞浸润、纤维组织增生和巨噬样A型细胞有明显抑制作用。
There is distinct diversity in specific antigens, histological distribution, inflammatory response and expressive receptors in rat macrophage subpopulations. 大鼠不同巨噬细胞亚群在特性抗原、组织分布、对炎症的反应、受体表达等均存在明显差异。
Conclusion: TA of TBL can inhibit the production of inflammatory cytokine such as IL-1 β, TNF-α secreted by macrophage and block the pathologic damnification induced by immune inflammation reaction. 结论:通痹灵总碱抑制巨噬细胞分泌炎性细胞因子IL-1β、TNF-α,进而抑制了一系列免疫炎症反应造成的病理损伤。
Effects of the inhalable particle ( PM_ ( 10)) on secretion of inflammatory factors in human lung fibroblasts and mouse alveolar macrophage cell 大气PM(10)对两种不同细胞分泌炎性细胞因子的影响
Objective To study the expression and purification of recombinant chemokine viral macrophage inflammatory protein ⅱ( vMIP ⅱ) in E. coli. 目的重组病毒巨噬细胞炎性蛋白Ⅱ(viralmacrophageinflammatoryproteinⅡ,vMIPⅡ)在大肠杆菌中表达及纯化。
Effect of Tongbiling ( TBL) Total alkaloids ( TA) on inflammatory cytokine secretion from macrophage stimulated by LPS 通痹灵总碱对LPS(脂多糖)刺激后的巨噬细胞产生炎性细胞因子的影响
Objective: To explore the biological activities of viral macrophage inflammatory protein ( vMIP) encoded by K6 gene of human herpesvirus 8. Methods: Combined ability of vMIP to receptors was measured by Cross-linking assays. 目的:探讨人疱疹病毒8K6基因编码的产物病毒巨噬细胞炎性蛋白(viralmacrophageinflammatoryprotein,vMIP)是否具有结合趋化因子受体以及趋化作用。方法:受体配体交联试验检测vMIP与受体结合能力。
There are different degrees of improve rat ankle injury, administration group had inflammatory cells, macrophage infiltration reduction; reduce the proliferation of synovial cells; angiogenesis; cartilage surface spalling visible flat. 大鼠踝关节损伤有不同程度的改善,给药组均有炎细胞、巨噬细胞浸润减少;滑膜细胞增生减轻;血管增生减少;软骨表面可见扁平层剥落。